Endoglin Upregulation in the Liver after Bile Duct Ligation in Rats
نویسندگان
چکیده
Background: Transforming growth factor beta 1 (TGF1) has been implicated in the stimulation of extracellular matrix synthesis in acute and chronic liver disease. Endoglin (CD-105) is a membrane glycoprotein that binds TGF1 with high affinity. Endoglin is overexpressed in several model of fibrosis. The goal of the present study was to evaluate the effect of bile duct ligation (BDL) on endoglin expression and the effect of endoglin overexpression on liver fibrosis
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